MASSIVELY PARALLEL REPORTER ASSAY CONFIRMS REGULATORY POTENTIAL OF HQTLS AND REVEALS IMPORTANT VARIANTS IN LUPUS AND OTHER AUTOIMMUNE DISEASES

Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases

Summary: We designed a massively parallel reporter assay (MPRA) in an Epstein-Barr virus transformed B cell line to directly characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs), expression QTLs (eQTLs), and variants on systemic lupus erythematosus (SLE) and autoimmune (AI) disease A

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Microstructural analysis of meat and internal organs of broiler chickens using a probiotic biological product

Probiotic preparation containing bacteria of the genus Bacillus subtilis and Bacillus licheniformis used for feeding broiler chickens to improve feed digestion, nutrient absorption, increase immune status and productivity, and for the prevention and treatment of various poultry OTR Microwave diseases.The purpose of the study is to conduct histologi

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Sex differences in neuromuscular androgen receptor expression and sociosexual behavior in a sex changing fish.

Androgen signaling, via receptor binding, is critical for regulating the physiological and morphological foundations of male-typical reproductive behavior in vertebrates.Muscles essential for male courtship behavior and copulation are highly sensitive to androgens.Differences in the distribution and density of the androgen receptor (AR) are importa

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3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

Out of millions of ejaculated sperm, a few reach the fertilization site in mammals.Flagellar Ca2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating CatSper-dependent mechanisms in sperm selection.Here using biochemical and pharmacological studies, we

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